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![]() ![]() Let’s hope Short gets it together the fourth time around. in November 2017, in accordance with Hollywood Masks opinions, the rapper has served sentence for supposedly hitting his partner. Short has also battled numerous criminal charges during the past couple of years, having spent six days in custody for violating the terms of his probation relating to a 2014 assault charge and serving another 24 hours in jail for failing a drug test at an in-patient drug rehab program at the Pasadena Recovery Center in California, WENN pointed out. Columbus launched his engagement to Aida Abramyan in August 2016 and the pair acquired married in December of 2016, they’ve two kids collectively. Prior to that, he was married to a woman named Brandi, who is the mother of his oldest son. The couple tied the knot in December 2016. McCall accused Short of being abusive and he was sentenced to three years probation and ordered to take a counseling course after pleading no contest to misdemeanor spousal battery in 2014. Former Scandal star Columbus Short has formally been charged following his domestic violence arrest earlier in February. So, who is Columbus Shorts wife He is currently married to Aida Abramyan. Prior to that, Short had an extremely hostile split from ex-wife Tanee McCall with whom he shares a four-year-old daughter. We found out the unlikely pair had jumped the broom in January of this year (though he claimed the union wasn’t legal) and by March, Steffans was calling him out as a cheater on social media. If you feel like it was just yesterday that we were discussing Short and Karrine Steffans tumultuous marriage, you’re right. Short told the police that Abramyan had punched him in the face despite no injuries visible at the time. He is now engaged to be married to girlfriend Aida Abramyan, who is expecting the couple’s first child. This will be the 33 year old’s third child. Columbus Short, 33, has some very exciting news after a rocky start to his 2016 year. The 39-year-old artist is married to his wife, Aida Abramyan Short, and has two kids together. Stomp the Yard, Cadillac Records, Armored, and The Losers are his best-known movies. He worked with Brian Friedman and choreographed Britney Spears' Onyx Hotel Tour. The pair plans to walk down the aisle in January 2017 before the little one arrives. Columbus Short is a choreographer and actor from the United States. Former ‘Scandal’ star Columbus Short was arrested for another alleged domestic dispute involving his wife, Aida Abramyan. Apparently the two have been dating on and off for years, but are now ready to make things official as they prepare to welcome their first child together, a son, Short confirmed to Entertainment Tonight. ![]() ![]() Patients suffering the chronic inflammatory and auto-immune diseases are routinely prescribed with glucocorticoids (dexamethasone/DEX and others 1). Collectively, these results show that PGK1 depletion protects human osteoblasts from DEX via activation of Keap1-Nrf2 signaling cascade. At last we show that PGK1 expression is downregulated in human necrotic femoral head tissues of DEX-taking patients, correlating with HO1 depletion. In addition, Keap1 shRNA mimicked and nullified PGK1 shRNA-induced anti-DEX osteoblast cytoprotection. Importantly, PGK1 depletion-induced osteoblast cytoprotection against DEX was almost abolished by Nrf2 shRNA. Furthermore, PGK1 knockout, by the CRISPR/Cas9 method, similarly induced Nrf2 signaling activation and protected osteoblasts from DEX. Functional studies demonstrated that PGK1 shRNA largely attenuated DEX-induced oxidative injury and following death of OB-6 cells and primary osteoblasts. ![]() Here, in OB-6 osteoblastic cells and primary human osteoblasts, PGK1 silencing, by targeted shRNA, induced Nrf2 signaling cascade activation, causing Nrf2 protein stabilization and nuclear translocation, as well as increased expression of ARE-dependent genes ( HO1, NQO1, and GCLC). A recent study has shown that phosphoglycerate kinase 1 (PGK1) inhibition/depletion will lead to Kelch-like ECH-associated protein 1 (Keap1) methylglyoxal modification, thereby activating Nrf2 signaling cascade. Activation of nuclear-factor-E2-related factor 2 (Nrf2) cascade can alleviate dexamethasone (DEX)-induced oxidative injury and death of human osteoblasts. |
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